Perhaps the most well researched form is curcumin phytosome. But before jumping into a discussion on curcumin phytosome, here is a little background on . Buy Doctor’s Best Curcumin Phytosome with Meriva, Non-GMO, Vegan, Gluten Free, Soy Free, Joint Support, mg Veggie Caps on Buy Doctor’s Best Curcumin Phytosome with Meriva, Non-GMO, Vegan, Gluten Free, Soy Free, Joint Support, mg 60 Veggie Caps on ✓ FREE .
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But why is curcumin so popular? Simply put, it is highly efficacious, and the research curcmin it is extensive. That being said, some forms of curcumin have significantly more research to support their efficacy than others. Perhaps the most well researched form is curcumin phytosome.
But before jumping into a discussion on curcumin phytosome, here is a little background on turmeric and curcumin. Phytosime member of the ginger family, turmeric has been used for as a traditional remedy in Chinese and Indian ayurvedic medicine as well as for condiment and flavoring purposes for more than 2, years, based on records dating back to BCE.
The medicinal part of turmeric is its rhizome, curcukin underground stem curcimin looks more like a root due to its thick appearance. Its primary active constituent comprising 0. Demethoxycurcumin and bisdemethoxycurcumin are two other major curcuminoids, although a significant body of modern scientific research documents the health benefits of curcumin. The limiting factor with curcumin is its poor biovailability—with 40 to 75 percent of curcumin passing through the digestive tract unchanged in animal research.
Phytosomes are made up by lecithin phospholipids from sunflower or soy sources. Curcumin phytosome is not a mixture of curcumin and the phospholipid, but rather a dispersion of curcumin into the phospholipids—like the way that mayonnaise is not a mixture of oil and egg yolk, but rather a dispersion of curcumkn yolk into an oily phase. The significance of this is that phytosomes can optimize the delivery of curcumin and other polyphenolics through the gastrointestinal tract.
The result is improved absorption. This was demonstrated in human research, 17 which phytosmoe that total curcuminoid absorption was about fold higher for curcumin curdumin Meriva, Indena than for ordinary curcumin. Animal research has also shown significantly higher absorption for curcumin phytosome. The results were the following improvements in the curcumin phytosome group:.
Results were that curcumin phytosome showed clear analgesic activity, comparable with 1, mg of acetaminophen, but lower than that of a therapeutic dose of nonsteroidal anti-inflammatory drug. Gastric tolerability was significantly better with curcumin phytosome than that of the other medications. It is also noteworthy cutcumin the walking distance at the treadmill test after one month was also significantly higher in the curcumin phytosome plus glucosamine group.
Although most readers will be familiar with osteoporosis, less are familiar with osteopenia, a chronic bone condition characterized by decreased phytosomd, density, or bone mass. If left untreated, it can lead to osteoporosis and bone fractures. The results showed bone densities significantly increased during the study in supplemented subjects, reaching as high as 7.
It is noteworthy that no significant changes bone density occurred with SM alone. In conclusion, this preliminary study suggests that curcumin phytosome supplementation in combination with an appropriate lifestyle could be beneficial in the prevention and management of osteopenia.
In addition, curcumin phytosome was well tolerated and could reduce eye discomfort symptoms and signs after a few weeks of treatment in more than 80 percent of patients. In conclusion, this study demonstrated the potential therapeutic role of curcumin and its efficacy in anterior uveitis, and points out other promising curcumin-related benefits in eye inflammatory and degenerative conditions, such as dry eye, maculopathy, glaucoma, and diabetic retinopathy.
A four-week pilot study 25 was conducted to evaluate the effect of mg, twice daily of curcumin phytosome Meriva, Indenacompared to a control group, on the improvement of diabetic microangiopathy weak, leaking capillaries and retinopathy damage to blood vessels in the retina in 38 diabetic patients.
Likewise, retinal blood flow, retinal edema, and visual acuity also showed improvement with curcumin phytosome; but there were no clinical or microcirculatory improvements in controls.
In conclusion, curcumin phytosome has value in the management of diabetic microangiopathy and retinopathy. In addition, a group of researchers conducted another study 26 in 25 patients with diabetic microangiopathy using the same dose of curcumin phytosome, with similar, and statistically significant results. An open-label study 27 was conducted to investigate the effect of mg, twice daily of curcumin phytosome Meriva, Indena on visual acuity and retinal thickness in 18 eyes from 12 patients with acute or chronic central serous chorioretinopathy a condition where fluid builds up under the retina, distorting vision.
Results were that, after six months of therapy, 0 percent of eyes showed reduction in visual acuity, 39 percent showed stabilization, and 61 percent showed improvement. After six months of therapy, 78 percent of eyes showed reduction of neuroretinal or retinal pigment epithelium detachment, 11 percent showed stabilization, and 11 percent showed an increase. A follow-up study 28 showed similar, and statistically significant results.
Dysfunction of meibomian glands MGD is among the most frequent causes of ocular discomfort. Results were that tear instability defined as tear breakup timeQuality of Life Test, interpalpebral corneal dye staining and lid margin inflammation all improved.
To test whether 1 g twice daily of curcumin phytosome Meriva, Indenaor placebo, could reduce damage from oxidative stress and inflammation related to acute muscle injury induced by eccentric continuous exercise, a randomized, placebo-controlled, single-blind pilot trial 30 was conducted with 20 healthy, moderately active male volunteers. Supplementation was initiated 48 hours prior to a phgtosome running test and was continued for 24 hours after the test four days in total.
Muscle damage was quantified by MRI and analyses on muscle samples obtained 48 hours after the test.
Jarrow Formulas : Curcumin Phytosome
Patient-reported pain intensity was also recorded. Results were that subjects in the curcumin group reported less pain in the lower limb as compared with subjects in the placebo group, with significant differences in the right and left anterior thighs. Significantly fewer subjects in the curcumin group had MRI evidence of muscle injury in the posterior or medial compartment of both thighs.
Increases in markers of muscle damage and inflammation tended to be lower in the curcumin group, with significant differences observed for interleukin-8 at two hours after exercise. In conclusion, curcumin phytosome has the potential for preventing delayed onset muscle soreness DOMSas suggested by its effects on pain intensity and muscle injury. Additional evidences for curcumin phytosome in muscular well-being are available.
The subjects freely decided to start one of the following interventions: In conclusion, the addition of curcumin phytosome, either or not combined with other dietary supplements, to standardized diet and exercise plan contributes to improve strength and physical performance in elderly subjects, potentially preventing the onset of sarcopenia. Another study with curcumin phytosome Meriva, Indena was undertaken since endurance exercise increases the production of the inflammatory IL-6 cytokine, and is thought to impair intracellular defense mechanisms—and in-vitro research has indicated that curcumin may help inhibit cytokine production.
In this study, 32 11 male recreational athletes consuming a low carb diet consumed a single mg of dose of curcumin phytosome with midday meal for three days, and then mg was ingested just before exercise to investigate the effect of supplementation on the cytokine and stress responses following two phytoosme of cycling.
Results were that curcumin phytosome appeared to lower the concentration of IL-6 released one hour following exercise when compared to placebo, although the difference did not reach statistical significance which may phytowome been due to the small study size.
Exercise-heat stress increases gastrointestinal barrier damage and the risk of exertional heat stroke. Over the past decade at least eight different dietary supplements have been tested for potential curcumni in gastrointestinal barrier function and systems-level physiology responses during exercise-heat stress, but none have been shown to protect against both insults simultaneously.
There were two major results from this study. First, curcumin phytosome supplementation reduced the rise in certain physiology parameters during exertional heat stress.
Second, these changes were accompanied by reductions in GI barrier damage and associated inflammatory cytokine responses. Collectively, these data suggest that short-term supplementation with curcumin phytosome may help to lower exercise-heat stress risk in non-heat acclimated individuals.
Nonalcoholic fatty liver disease NAFLD is one of the most common liver diseases in the general adult population. Cholesterol phyyosome triglyceride problems, high uric acid levels, and insulin resistance are common risk factors of NAFLD.
All patients received dietary and lifestyle advises before the start of phytosoke.
The many applications of Curcumin Phytosome
Anthropometric measurements, lipid profile, glucose, insulin, glycated hemoglobin and uric acid concentrations were measured crcumin baseline and after eight weeks of follow-up. In conclusion, curcumin phytosome supplementation reduced serum lipids and uric acid concentrations in patients with NAFLD. Subsequently, a second study 35 of the same length was conducted on NAFLD, using the same number of subjects and the same dose of curcumin phytosome.
Anthropometric pphytosome, hepatic enzymes and liver ultrasonography were assessed at baseline and after eight weeks of follow-up. Results were that supplementation with curcumin phytosome was associated with a reduction in body curcumon index of Waist circumference deceased Liver ultrasound findings were improved in 75 percent of subjects in the curcumin phytosome group, while the rate of improvement in the control group was only 4.
Patients in Group A served as controls and did not receive any treatment either before or after surgery. Patients in Group B received oral supplementation twice a day for three months both before and after surgery totaling six months of supplementation.
Patients in Group C received oral supplementation twice a day for three months before surgery only. Results were that patients in Group B showed significantly lower nocturnal symptoms scores compared cyrcumin Group A subjects at both 40 days and three months after surgery both values. In conclusion, curcumin phytosome in combination with alpha-lipoic acid and B-vitamins twice a day both before and after surgery is safe and effective puytosome CTS patients scheduled to undergo surgical treatment for CTS.
Sixty-three patients with mild-to-moderate psoriasis vulgaris were randomly divided into two groups phytoeome with topical steroids and curcumin phytosome arm 1or with topical steroids alone arm 2both for 12 weeks. At the beginning and at the end of the therapy week 12clinical assessment and immunoenzymatic analysis of the serum levels of IL and IL were performed.
Phttosome week 12, both groups achieved a significant reduction of PASI values. However, that value was higher in patients treated with both topical steroids and oral curcumin than in patients treated only with topical steroids.
Moreover, IL serum levels were significantly reduced in patients treated with curcumin phytosome. In conclusion, curcumin was demonstrated to be effective as an adjuvant therapy for pgytosome treatment of psoriasis vulgaris and to significantly reduce serum levels of IL The aim of this study 38 was to compare two management plans in the treatment of 61 men with symptomatic benign prostatic hyperplasia BPH.
No side effects were recorded. In conclusion, the addition of curcumin phytosome to BSM treatment contributed to phyosome reduction of signs and symptoms of the disease without causing any significant additional side effect. Curcumin is a popular dietary supplement, phytozome its popularity shows no signs cucumin abating according to sales projections. Grand View Research, Inc. Retrieved February 6, from https: Curcumin Market will exceed USD million by Retrieved February 5, from https: Curcumin and Joint Health: From Traditional Knowledge to Clinical Validation.
Therapeutic Guide to Herbal Medicines. American Botanical Council; A review of plants used in the treatment of liver disease: Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers.
Pharmacokinetics of curcumin conjugate metabolites in healthy human subjects. Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions.