Propos. – La maladie de Castleman est une prolifération lymphoplasmocytaire polyclonale et vasculaire prédominant au sein des structures lymphoïdes. Revue de Pneumologie Clinique – Vol. 69 – N° 1 – p. – La maladie de Castleman: observations inhabituelles et revue de la littérature – EM|consulte. 1. Oksenhendler E., et al. Multicentric Castleman’s disease in HIV infection : a clinical and pathological study of 20 patients. AIDS 2. Soulier J.
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Le pronostic est sombre. Les infections opportunistes, propre au terrain sida aggravent ce pronostic. It is associated with lymph node enlargement, hepatosplenomegaly and fever. This castlemxn could be secondary to hyperproduction of interleukin 6.
maladoe The prognosis is poor. The opportunistic infections which are characteristic of severe HIV infection worsen the prognosis. Prolonged monochemotherapy with vinblastine or etoposide can control Castleman’s disease. Current knowledge and key points.
Indeed, HHV8 produce an homologous interleukin 6, the vIL-6, responsible for lymphoplasmacytic proliferation. The presence of other homologues of human cytokines produced by HHV8 could contribute to lymphoplasmacytosis and to endothelial proliferation.
La maladie de Castleman : observations inhabituelles et revue de la littérature – EM|consulte
However, antiviral therapy against HHV8 or HIV and the immunitary restoration do not have any influence on the evolution of Castleman’s disease, contrary to opportunistic infections. Previous Article La camptocormie: Journal page Archives Contents list.
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Maladie de Castleman chez les patients infectés par le VIH – EM|consulte
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